
TREATMENT
POLYNUCLEOTIDES
Polynucleotides (also known as PDRN: polydeoxyribonucleotide) are an advanced injectable treatment derived from highly purified salmon or trout DNA, which shares a close molecular affinity with human DNA. When injected into the skin, polynucleotides stimulate fibroblast activity, accelerate tissue repair, and promote deep hydration by binding water molecules at a structural level. The result is genuine skin regeneration — not just surface improvement.
FAST
NUMBING CREAM
RECOVERY
ANAESTHETIC
9-18 MONTHS
DURATION
30 MINS
TIME TAKEN

TIME TAKEN
DURATION
ANAESTHETIC
RECOVERY
30 MINS
3-6 MONTHS
NUMBING CREAM
FAST
What it treats:
- Skin laxity and loss of firmness
- Fine lines and crepey skin texture
- Under-eye hollowing and dark circles
- Sun-damaged and dehydrated skin
- Post-acne scarring
- Hair thinning and scalp health
- Overall skin quality and radiance
What to expect: Treatment involves a series of small, shallow injections across the treatment area. There is minimal discomfort; mild redness or pinprick marks settle within a few hours. Sessions take 30–45 minutes.
Results: Polynucleotides work progressively. Most patients notice improved hydration and texture from the first session, with significant regenerative results building over 4–8 weeks. A course of 3 sessions, 2–4 weeks apart, is standard, followed by maintenance every 3–6 months.
Good to know: Polynucleotides are among the most evidence-backed biostimulator treatments available and have been used in medical settings for decades. They are an excellent choice for patients seeking a natural, regenerative approach rather than volume addition.
QUESTIONS ABOUT CHEEK FILLERS
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Does cheek fillers hurt?
Profhilo may produce some minor discomfort, which can easily be reduced with the application of a topical numbing cream prior to the procedure.
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How different will I look following cheek fillers?
We will discuss your desired outcome at your pre-treatment consultation. Depending on the extent of treatment required, the results can be subtle or more dramatic (in the case that a non-surgical facelift is desirable), but we don’t aim to change the way look, so you will still look just like you, only refreshed! We can create amazing results with cheek fillers that will leave you feeling confident and like your more youthful self.
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How much are cheek fillers?
For the costs, please check out the pricing section of The REAL Clinic's website.
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WOULD YOU LIKE A LITTLE EXTRA HELP?
If you’re not sure what treatment you need, or you would just like a chat to get some advice, give our team a call or drop us a message and we’ll be happy to help.





